Concerning difficulties of adult life - I think there are many options.
As I've noticed in your message that you made introduction to your query - and it's one quarter of socializing trick in my opinion (to realize what part of information is new for other people), you are capable of asking questions about information you need (that's also one quarter), another one quarter is a job qualification (and that's education for) and the last one - is pure human communication like face expressions, gestures, movements and so on.
I mostly lack the last from the list but I manage by asking questions (because even NT can miss something and ask to clarify - why shouldn't I do the same?) and accepting that most part of people-related information (like their personal life or relationship between each other and such) I miss totally. But, honestly, that sort of information changes so quickly, I don't really think it to be important to know about people I barely contact personally. I keep tabs on people I contact a lot.
For communication in the group I use my understanding what kind of relationship connects me to every person from the group.
Actually it's a working etiquette - to not base my attitude to a colleague on my knowldge about her/his personal relationship with someone else. For me it just comes naturally - since I don't know it anyway
But the other side of not knowing 'who is close to whom' is that I have to be very acurate about my words - to not show being upset (and speak aloud) with persons but - with tasks that were not done properly (impersonally). That evokes other people's sympathy to me - but being angry with someone personally may get me an unexpected enemy because of interpersonal relationship I'm not aware of.
Actually everything else besides work is mostly optional: like I hate cooking (I can cook chicken, rice and buckwheat. I can chop tomatoes and cucumbers for a salade, and really I don't need much more), be clean mostly gets along with my sense of myself - it's not a chore for me (unless I'm tired), living alone - I learnt and got to love it, sexually needs - I haven't yet met a person I would feel comfortable around and interested in trying it but I'm not obsessed with the fact (if I meet someone like this - it's fine, if not - I'll live just fine without) and so on.
It's your life to live and fill it with whatever you feel like doing.